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. Author manuscript; available in PMC: 2011 May 1.

Published in final edited form as: Biomaterials. 2010 Feb 13;31(14):4146–4156. doi: 10.1016/j.biomaterials.2010.01.112

In vitro colistin release from PMMA/CMC/PLGA constructs: A) The cumulative colistin release from PLGA/PMMA/CMC constructs presented a continuous colistin release over a period of 5 weeks. The total released colistin varied between 68.1±3.3-88.3±5.8% depending on the composition of the construct. Statistical significance between relevant groups is denoted by * and ** (p<0.05). B) The daily release of colistin, described as the concentration of released colistin divided by the corresponding release time in days, demonstrated that a constantly high colistin concentration (well above the reported MIC of colistin against its susceptible species) was created via controlled colistin release over 5 weeks. Error bars represent standard deviation for n=3.

In vitro colistin release from PMMA/CMC/PLGA constructs: A) The cumulative colistin release from PLGA/PMMA/CMC constructs presented a continuous colistin release over a period of 5 weeks. The total released colistin varied between 68.1±3.3-88.3±5.8% depending on the composition of the construct. Statistical significance between relevant groups is denoted by * and ** (p<0.05). B) The daily release of colistin, described as the concentration of released colistin divided by the corresponding release time in days, demonstrated that a constantly high colistin concentration (well above the reported MIC of colistin against its susceptible species) was created via controlled colistin release over 5 weeks. Error bars represent standard deviation for n=3.