Table 3.
Age-adjusted telomere length and plasma total antioxidant status (TAOS) measures by UCP2 functional SNPs in Caucasian type 2 diabetes patients.
| UCP2 SNP/haplotype | %Genotype/haplotype (N) | Telomere length (kb)a | p-Value | TAOS (%)b | p-Value |
|---|---|---|---|---|---|
| −866G>A (rs659366) | |||||
| GG | 40.8 (231) | 7.03 (6.91–7.15) | 0.11 | 45.6 [35.4–54.2] | 0.20 (0.08 for trend) |
| GA | 46.5 (263) | 6.86 (6.75–6.98) | 44.3 [35.7–51.7] | ||
| AA | 12.7 (72) | 6.84 (6.63–7.06) | 42.1 [34.1–48.7] | ||
| GA/AA | 59.2 (335) | 6.86 (6.76–6.96) | 0.04 | 43.9 [35.4–50.7] | 0.17 |
| A55V (rs660339) | |||||
| CC | 35.5 (193) | 7 (6.86–7.14) | 0.24 | 45.8 [35.3–54.6] | 0.05 (0.03 for trend) |
| CT | 48.4 (263) | 6.9 (6.79–7.02) | 44.7 [365.–52.8] | ||
| TT | 16.2 (88) | 6.8 (6.62–6.99) | 41.8 [32.1–48.5] | ||
| CT/TT | 64.5 (351) | 6.87 (6.78–6.97) | 0.15 | 44 [35.4–50.9] | 0.20 |
| −866G>A/A55Vc | |||||
| G/C | 63.0 | 6.98 (6.83–7.14) | 44.8 [42.4–47.2] | ||
| G/T | 4.0 | 6.89 (6.06–7.91) | 0.85 | 42.0 [30.1–53.9] | 0.03 |
| A/T | 33.0 | 6.79 (6.56–7.04) | 0.25 | 39.4 [35.6–43.1] | 0.65 |
All haplotypes with frequency <2% are excluded from the analysis.
a
Data were log-transformed and the geometric mean (95%CI) was then used to calculate the corresponding telomere length in kb.
b
median [IQR] is presented.
c
Data is presented for 2 copies of each haplotype.