TABLE 3.

Standardized incidence ratio of cancer occurrence in 8,093 Danish patients with oral clefts during follow-up from 1943 to 1998^*

ICD-7† codes	Observed (no.)	Expected (no.)	Standardized incidence ratio	95% confidence interval
140–205 (all minus other skin cancers)‡	140	131.00	1.07	0.90, 1.26
150–159 (digestive organs and peritoneum)	14	15.50	0.90	0.49, 1.52
153 (colon, including rectosigmoid)	6	5.40	1.11	0.41, 2.42
160–164 (respiratory system)	14	11.55	1.21	0.66, 2.03
161 (larynx)	3	1.28	2.34	0.47, 6.85
162.0–162.1 (lung primary, tracheae)	11	9.42	1.17	0.58, 2.09
162.x (non-small cell lung cancer)	10	7.67	1.30	0.62, 2.40
170 (breast)	33	21.64	1.52§	1.05, 2.14
171–176 (female genital organs)	10	12.85	0.78	0.37, 1.43
171 (cervix uteri)	6	6.99	0.86	0.31, 1.87
175 (ovary, fallopian tube, broad ligaments)	4	3.48	1.15	0.31, 2.94
177–179 (male genital organs)	12	11.59	1.04	0.53, 1.81
178 (testis)	10	10.38	0.96	0.46, 1.77
180–181 (urinary system)	10	7.53	1.33	0.64, 2.44
181 (bladder including papilloma)	8	4.38	1.83	0.79, 3.60
192–197 (other specified sites)	17	17.59	0.97	0.56, 1.55
193 (brain and nervous system)	12	12.30	0.98	0.50, 1.70
200–205 (lymphatic and hematopoietic tissue)	19	16.57	1.15	0.69, 1.79
200, 202 (non-Hodgkin’s lymphoma)	3	5.51	0.54	0.11, 1.59
201 (Hodgkin’s disease)	6	3.60	1.67	0.61, 3.63
204 (leukemia)	9	6.59	1.36	0.62, 2.59
204.1 (acute myelogenous leukemia)	3	1.83	1.64	0.33, 4.80

^*A total of 52 sites were studied, but only sites with three or more observed cases are shown. Nonmelanoma skin cancers are excluded because of underreporting.

^†ICD-7, International Classification of Diseases, Seventh Revision.

^‡ICD-7 (modified version) code 191.

^§Statistically significant standardized incidence ratio.