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. 2010 Mar 15;207(3):553–564. doi: 10.1084/jem.20090858

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© 2010 Masopust et al.

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Figure 6. — Primary human CD8 T cell response to s.c. yellow fever vaccine results in only short-term expression of α4β7 and CLA. Blood was isolated from HLA-A2–positive volunteers 11, 14, 30, and 90 d after s.c. vaccination with YFV-17D. (A) Expression of CLA versus staining with MHC class I tetramers that recognize YFV-specific CD8 T cells from three representative patients. (B) CLA versus α4β7 expression. HLA2-YFV tetramer⁺ cells are blue and HLA2-YFV tetramer⁻ cells are gray. Numbers indicate percentage of tetramer⁺ cells in each quadrant. All plots are gated on CD3⁺ CD8⁺ lymphocytes. (C) Summary of CLA and α4β7 expression among YFV tetramer⁺ cells. Longitudinal analysis is shown, although some patients were not examined on days 30 and 90. Horizontal bars show the mean. Day 11, n = 7; day 14, n = 7; day 30, n = 4; day 90, n = 6.