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. Author manuscript; available in PMC: 2011 Jan 1.
Published in final edited form as: Biochem Biophys Res Commun. 2009 Nov 27;391(1):835–840. doi: 10.1016/j.bbrc.2009.11.148

Fig 1.

Fig 1

Effect of diet on survival and motor phenotype of SMNΔ7 SMA mice. (A). Kaplan-Meier survival plots of SMNΔ7 SMA mice from dams transitioned from the Harlan-Teklad 22/5 diet to the PicoLab20 Mouse diet. (B). Kaplan-Meier analysis of the onset of body mass loss an indicator of the late stages of disease in SMNΔ7 SMA mice from dams fed the PicoLab20 Mouse diet or the Harlan-Teklad 22/5 diet. (C). Body mass curves for SMNΔ7 SMA mice as well as WT littermates from dams fed either the PicoLab 20 Mouse or the Harlan-Teklad 22/5 diets. Key: *, p<0.05 when comparing SMNΔ7 SMA to WT mice. (D) Righting reflex latencies for SMNΔ7 SMA mice as well as WT littermates at PND07 and PND11 from dams fed either the PicoLab20 Mouse diet of the Harlan-Teklad 22/5 diet. (E) Vectorial movement latencies for SMNΔ7 SMA mice as well as WT littermates at PND07, PND11 and PND14 from dams fed either the PicoLab20 Mouse diet of the Harlan-Teklad 22/5 diet. (F) Spontaneous locomotor activity—as measured by the number of grids crossed in 1 minute—for SMNΔ7 SMA mice as well as WT littermates at PND07, PND11 and PND14 from dams fed either the PicoLab20 Mouse diet of the Harlan-Teklad 22/5 diet. (G) The number of 90° pivots in 1 minute for SMNΔ7 SMA mice as well as WT littermates at PND07, PND11 and PND14 from dams fed either the PicoLab20 Mouse diet of the Harlan-Teklad 22/5 diet. Key: *, p<0.05 when comparing SMNΔ7 SMA to WT mice; #, p<0.05 when comparing PicoLab20-fed to Harlan-Teklad 22/5-fed mice. (H). Effect of diet on motor neuron numbers in the lumbar spinal cords of SMNΔ7 SMA mice at PND11. Key: *, p<0.05 when comparing SMNΔ7 SMA to WT mice.