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Simplified illustration of the epidermal growth factor receptor (EGFR) pathway with the RAS/MAPK and PIK3CA/PTEN cascades. Specific components of the pathway are correlated with resistance to anti-EGFR monoclonal antibodies (moAbs). As shown, KRAS and BRAF mutations are correlated with resistance to anti-EGFR moAbs, while further evaluation is required for PIK3CA mutations and PTEN loss of expression.
