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. 2009 Nov 10;18(1):135–142. doi: 10.1038/mt.2009.257

Figure 1.

Figure 1

Proteasome inhibitor mediated enhancement of gene expression following AAV2 transduction in vitro. (a) HHL5 cells were transduced with AAV2-CMV-LacZ (MOI 10,000) with the proteasome inhibitors MG-132, lactacystin, or bortezomib at the concentrations indicated. LacZ expression was measured 24 hours after transduction. (b) 293 or (c) Hepa 1-6 cells were transduced with AAV2-CMV-LacZ (MOI 10,000) in the presence of increasing amounts of bortezomib. LacZ expression was measured 24 hours after transduction. All experiments are performed in triplicate and SEM is shown. AAV, Adeno-associated virus; CMV, cytomegalovirus; MOI, multiplicity of infection.