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. 2009 Oct 27;18(1):17–22. doi: 10.1038/mt.2009.250

Figure 1.

Figure 1

Dose-response of hepatic HMB-synthase expression. AIP mice were administered 3.8 × 1011, 5.7 × 1011, or 7.6 × 1011 drp of rAAV2/8-HMBS and the hepatic HMB-synthase activities were determined 1 week later. Black bars represent HMB-synthase activities detected in the AIP (T1/T2) mice, whereas the white bar represents that of saline-treated wild-type (wt/wt) mice. Data are presented as mean + SD (n = 4). AIP, acute intermittent porphyria.