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. 2009 Oct 27;18(1):17–22. doi: 10.1038/mt.2009.250

Figure 5.

Figure 5

Effect of rAAV2/8-HMBS therapy on neuromotor function. (a) Seven month old male wild-type (wt/wt) and saline- and rAAV2/8-HMBS-treated AIP (T1/T2) mice were evaluated for their performance on a rotarod rotating at 16 rpm, for a maximal time of 180 seconds. The results are expressed as means and standard deviations (n = 5). (b) Gait patterns were analyzed in nine month old mice by footprint analysis. Representative footprints of wild-type and saline- and rAAV2/8-HMBS-treated AIP mice are shown. LSLs were measured and statistically evaluated as described in the “Materials and Methods” section (n = 4–6). AIP, acute intermittent porphyria; LSL, left stride length.