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. 2009 Nov 3;18(1):151–160. doi: 10.1038/mt.2009.251

Figure 1.

Figure 1

Adeno-associated virus (AAV) vectors used in this study. (a) The first vector used in this study consists of the Rous sarcoma virus promoter (pRSV), a chimeric intron, the coding sequence of the immunosuppressive molecule LEA29Y, the woodchuck hepatitis virus post-transcriptional regulatory element (WPRE) and the SV40 polyadenylation signal (SV40 pA). (b) The second vector used in this study encodes the cynomolgus macaque erythropoietin (cmEpo) under the control of the doxycycline-inducible Ptet−1 promoter and the rtTA-M2 chimeric protein under the control of the muscle-specific 1-kb human desmin promoter (pDesmin). Arrows indicate the transcription start sites. BGH pA, bovine growth hormone polyadenylation signal; ITR, inverted terminal repeat sequence of AAV2.