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. 2009 Sep 15;18(1):188–197. doi: 10.1038/mt.2009.219

Figure 1.

Figure 1

Analysis of isolated JG-ODNs. (a) The scheme of intramolecular G-quartet structures of JG243, JG244, and T40214. (b) Histogram of the distribution of H bonds formed between JG244 and C-terminal domain of HIF-1α. (c) Nondenaturing gel electrophoresis of T40214 and JG-ODNs (JG240–JG249). (d) NMR spectrum of JG244. In the spectrum, the chemical shifts of imino protons of all residues are located at 10.5–12.0 ppm, showing that JG244 forms a stable G-quartet molecular structure. Inset: the arrows point to the imino protons in a G-quartet formation. HIF-1 hypoxia-inducible factor-1; NMR, nuclear magnetic resonance; ODN, oligodeoxynucleotide.