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JG-ODN suppresses the expression of HIF-1α-regulated genes. Quantitative real-time RT-PCR analysis of mRNAs encoding (a) VEGF and (b) GLUT1 in cells exposed to 20% O 2 or 1% O2. (c) JG243 and JG244 strongly suppressed the levels of HIF-1α, HIF-2α, Bcl-2, and Bcl-XL under hypoxia, but did not affect the expression of p53 or β-actin. Ctl, control; HIF-1, hypoxia-inducible factor-1; ns-ODN, nonspecific oligodeoxynucleotide.
