JG-ODNs inhibit the growth of prostate and breast tumor xenografts. (a) Plot of fold increases in tumor volume of prostate tumors versus days of drug treatment. (b) Nude mice with prostate tumors (PC3) treated with PEI, JG243/PEI, and JG244/PEI, respectively. (c) Plot of fold increases in tumor volume of breast tumors versus days of drug treatment. (d) Nude mice with breast tumors (MDA-MB-468) treated with PEI, JG243/PEI, and JG244/PEI, respectively. The excised tumor and its weight (g) are shown below each mouse. (e) Plot of fold increases in tumor volume of pancreatic tumors versus days of drug treatment versus days of drug treatment. (f) Nude mice with pancreatic tumor xenografts that were treated with PEI, JG243/PEI, and JG244/PEI, respectively. ODN, oligodeoxynucleotide; PEI, polyethylenimine.