Figure 6.

JG-ODNs specifically inhibit HIF-1α and HIF-2α expression in tumor xenografts. Lysates were prepared from (a) breast and (b) prostate tumor xenografts at the end of treatment and subjected to immunoblot assays using antibodies against the indicated proteins. Control, tumor from untreated mouse; JG243, tumor from mouse treated with JG243/PEI; JG244, tumor from mouse treated with JG244/PEI; PEI, tumor from mouse treated with PEI alone. Cont, control; HIF-1, hypoxia-inducible factor-1; ODN, oligodeoxynucleotide; PEI, polyethylenimine; VEGF, vascular endothelial growth factor.