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. 2009 Oct 20;18(1):198–205. doi: 10.1038/mt.2009.248

Figure 5.

Figure 5

PPMO treatment improves muscle function in dKO mice. (a) Forelimb muscle function was assessed using a functional grip strength test to determine the physical improvement of PPMO-treated dKO mice compared with untreated dKO mice and C57BL6 normal control mice (N = 6/cohort). ***P < 0.005 compared to untreated dKO mice and no significant difference to C57BL6 control mice. (b) Extensor digitorum longus (EDL) muscles of PPMO-treated dKO mice were analyzed for their maximal force (peak force) producing capacity compared to untreated dKO mice and C57BL6 control mice. (c) Maximal force was also normalized for cross-sectional area to assess specific force. **P < 0.01 compared to untreated dKO mice and no significant difference to C57BL6. (d) The percentage of Force drop is assessed by measuring the force deficit following a series of five eccentric contractions. *P < 0.05 compared to untreated dKO mice and no significant difference to C57BL6 control mice. Error bars are shown as mean ± SEM (N = 5/cohort). dKO, double-knockout; PPMO, peptide-conjugated phosphorodiamidate morpholino oligomer.