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. 1980 Jun;17(6):1032–1033. doi: 10.1128/aac.17.6.1032

Inhibition of herpes simplex virus multiplication by the pokeweed antiviral protein.

G M Aron, J D Irvin
PMCID: PMC283924  PMID: 6250468

Abstract

The pokeweed antiviral protein inhibited the multiplication of herpes simplex virus type 1 in cell culture. The extent of antiviral activity was proportional to the length of time that the antiviral protein was present postinfection. The results demonstrate that the continued presence of the pokeweed antiviral protein is necessary for the maximum inhibition of virus yields.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Dreesman G. R., Benyesh-Melnick M. Spectrum of human cytomegalovirus complement-fixing antigens. J Immunol. 1967 Dec;99(6):1106–1114. [PubMed] [Google Scholar]
  2. Irvin J. D., Kelly T., Robertus J. D. Purification and properties of a second antiviral protein from Phytolacca americana which inactivates eukaryotic ribosomes. Arch Biochem Biophys. 1980 Apr 1;200(2):418–425. doi: 10.1016/0003-9861(80)90372-0. [DOI] [PubMed] [Google Scholar]
  3. Irvin J. D. Purification and partial characterization of the antiviral protein from Phytolacca americana which inhibits eukaryotic protein synthesis. Arch Biochem Biophys. 1975 Aug;169(2):522–528. doi: 10.1016/0003-9861(75)90195-2. [DOI] [PubMed] [Google Scholar]
  4. Obrig T. G., Irvin J. D., Hardesty B. The effect of an antiviral peptide on the ribosomal reactions of the peptide elongation enzymes, EF-I and EF-II. Arch Biochem Biophys. 1973 Apr;155(2):278–289. doi: 10.1016/0003-9861(73)90116-1. [DOI] [PubMed] [Google Scholar]
  5. Tomlinson J. A., Walker V. M., Flewett T. H., Barclay G. R. The inhibition of infection by cucumber mosaic virus and influenza virus by extracts from Phytolacca americana. J Gen Virol. 1974 Feb;22(2):225–232. doi: 10.1099/0022-1317-22-2-225. [DOI] [PubMed] [Google Scholar]
  6. Ussery M. A., Irvin J. D., Hardesty B. Inhibition of poliovirus replication by a plant antiviral peptide. Ann N Y Acad Sci. 1977 Mar 4;284:431–440. doi: 10.1111/j.1749-6632.1977.tb21979.x. [DOI] [PubMed] [Google Scholar]
  7. Wyatt S. D., Shepherd R. J. Isolation and characterization of a virus inhibitor from Phytolacca americana. Phytopathology. 1969 Dec;59(12):1787–1794. [PubMed] [Google Scholar]

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