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. Author manuscript; available in PMC: 2010 Mar 16.
Published in final edited form as: Tetrahedron Asymmetry. 2009 Jan 30;20(1):1–63. doi: 10.1016/j.tetasy.2009.01.002

Table 13.

Asymmetric cyclization of serine derivatives.

graphic file with name nihms166053t28.jpg
entry substrate product Yield (%) ee (%)
1 672a; R = t-Bu 675a; n = 2 74 92 a
2 673a; R = Bn 676a; n = 3 84 86 (S)
3 673b; R = Me 676b; n = 3 75 82 (S)
4 673c; R = MOM 676c; n = 3 72 82 (S)
5 673d; R = TBDPS 676d; n = 3 13 88 (S)
6 673e; R = PMB 676e; n = 3 88 92 (S)
7 673f; R = t-Bu 676f; n = 3 89 93 (S)
8 674a; R = t-Bu 677a; n = 4 77 94 a
a

The configuration was not reported.