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Functional characterization of different compounds included in this study at human 5-HT7 receptors by measuring cAMP formation
| Compound | Antagonists |
Agonists |
|
|---|---|---|---|
| KB (nM) | EC50 (nM) | Emax (% of 5-CT) | |
| Mr22423 | 1402.23 ± 582.62 | 33.06 ± 3.12 | |
| mr22433 | 764.74 ± 54.46 | 21.69 ± 0.35 | |
| mr23284 | 302.67 ± 93.41 | 38.68 ± 3.51 | |
| mr25020 | 57.96 ± 0.18 | ||
| mr25040 | 82.00 ± 33.36 | ||
| mr25052 | 209.12 ± 105.23 | 28.99 ± 5.42 | |
| mr25053 | 37.48 ± 10.32 | ||
