Figure 3.
Growth curves of DU-145 tumor xenografts treated with microbubble/ultrasound-guided Ad-GFP, Ad.mda-7, or cancer terminator virus (CTV). Subcutaneous tumor xenografts from DU-145 cells were established in athymic nude mice in both right and left flanks and only tumors on the right side were sonoporated following tail-vein injection of the indicated microbubble/Ad complexes during a course of 4 weeks. Tumor treatments were initiated when tumors reached a size of 25–35 mm3. (a,c,e) Photographs of animals representative of each group. Black arrows indicate tumors. (b) Measurement of GFP-treated DU-145 tumor volumes. The data represent mean ± SD with at least 6 mice in each group. (d) Measurement of Ad.mda-7-treated DU-145 tumor volumes. The data represent mean ± SD with at least 9 mice in each group. (f) Measurement of CTV-treated DU-145 tumor volumes. The data represent mean ± SD with at least 9 mice in each group. Asterisks indicate treatment times. Ad, adenovirus; GFP, green fluorescent protein.