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. 2009 Sep 8;18(2):264–274. doi: 10.1038/mt.2009.205

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Copyright 2010, The American Society of Gene & Cell Therapy

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Therapeutic efficacy of combining Ad-ΔB7/IL-12/4-1BBL and DCs in spontaneous pulmonary metastasis model. (a) Representative lung macroscopic view of each group. Considerably less metastatic lesions were visible in lungs of mice treated with Ad-ΔB7/IL-12/4-1BBL and DCs. (b) Comparison of lung weight from each group. Significant inhibition of spontaneous lung metastasis was observed with combination of Ad-ΔB7/IL-12/4-1BBL and DCs (P < 0.05 versus Ad-ΔB7/IL-12/4-1BBL alone). DC, dendritc cell; PBS, phosphate-buffered saline.