Table 1.
Rank Correlations of Various Factors with dN or dN/dS
| Gene properties | ρ (P value) for correlation with dN | ρ (P value) for correlation with dN/dS |
| Mammals | ||
| Extracell | 0.177 (6.28e−11) | 0.166 (1.17e−09) |
| 5′UTR | −0.144 (9.75e−08) | −0.133 (9.71e−07) |
| Essen | −0.128 (2.21e−06) | −0.101 (1.88e−4) |
| TissSpcf | 0.122 (6.88e−06) | 0.096 (4.23e−4) |
| KPPI | −0.104 (1.21e−4) | −0.103 (1.42e−4) |
| 3′UTR | −0.085 (1.71e−3) | −0.079 (3.71e−3) |
| Intron | −0.075 (5.72e−3) | −0.077 (4.48e−3) |
| ExpLev | −0.038 (0.165) | −0.060 (0.028) |
| Yeasts | ||
| ExpLev | −0.541 (2.65e−215) | −0.473 (1.22e−158) |
| Essen | 0.197 (2.73e−26) | 0.202 (1.57e−27) |
| KPPI | −0.122 (5.80e−11) | −0.151 (7.36e−16) |
| Extracell | 0.022 (0.246) | 0.022 (0.232) |
NOTE.—Extracell is 1 for extracellular proteins and 0 for intracellular proteins. Essen is 1 for essential genes and 0 for nonessential genes. “UTR” is UTR length and “Intron” is average length per intron. “KPPI” is the number of interacting proteins. “TissSpcf” is tissue-specificity. “ExpLev” is gene expression level. P values show the probabilities of the observations under the hypothesis of no correlation. The analysis is based on 1,350 mouse–rat orthologs or 2,840 Saccharomyces cerevisiae–S. paradoxus orthologs.