CD4+ T cells were incubated with IL-12 and IL-18 were either cultured alone, co-cultured in the presence or absence of blocking TL1A Ab (04H08) or isotype control Ab with autologous monocytes (A, C) or monocyte-derived DC (B) that had been preincubated with bacteria or IC. After 48 h, media were collected and analyzed for IFN-γ production by ELISA. Closed circles represent values for each individual experiment, bars represent the mean value for each condition. *, p<0.05. **, p<0.001.