Figure 5.

Aqueous humor flow rates in animals with and without sustained reduction of IOP. Treated eyes that maintained a large decrease in IOP (i.e., all animals treated with at least COX-2^co and FPR^co, n = 6) had flow rates that were not significantly different from flow rates in control left eyes (mean change in flow rate = 0.02 ± 1.01 µl/min, i.e., <1%, P > 0.9). Aqueous humor flow rate would have to have been reduced by 48% to have reduced IOP by the 5.07 mm Hg (32%) observed in treated eyes with sustained IOP reduction. By using the fluorophotometry method, we had an 80% probability (β = 0.2) of finding an actual reduction of at least 22% in flow rate, if flow had been suppressed by this much. The reduction in pressure could not be explained by an undetected difference in flow this small. Cats lacking sustained IOP reduction: all subjects in groups 1, 2, and 5. Cats with sustained IOP reduction: all subjects in groups 3 and 4. L, left; R, right. Bars represent mean flow rate of six or more eyes. Error bars represent 95% confidence intervals. IOP, intraocular pressure.