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D2 dopamine autoreceptor function in control and coloboma mice. Striatal DOPA accumulation was assessed in the presence and absence of quinpirole (Quin). Basal levels of DOPA accumulation were comparable in control and coloboma mice. Two-factor ANOVA revealed a significant main effect of quinpirole treatment (F1,28 = 24.3, p < 0.0001) without significant effects of genotype or of treatment × genotype interactions. Values are means ± SEMs (n = 8/group).
