. 2010 Feb 3;19(3):297–310. doi: 10.1007/s00787-010-0096-6

Table 1.

Genetic variants with a polygenic effect on body weight in humans

SNP	Chr	Position	Nearest gene	Sample size in the original publication^a	Frequency of the risk allele (risk allele)	Effect on BMI in the original publication	References
rs2815752	1	72,524,461	NEGR1	32,387	62% (A)	+0.10 kg/m² per A allele^b	[92]
rs2568958	1	72,537,704	NEGR1	25,344	58% (A)	+0.43 kg/m² for AA genotype^c	[84]
rs10913469	1	176,180,142	SEC16B, RASAL2	25,344	20% (C)	+0.50 kg/m² for CC genotype^c	[84]
rs6548238	2	624,905	TMEM18	32,387	84% (C)	+0.26 kg/m² per C allele^b	[92]
rs7561317	2	634,953	TMEM18	25,344	84% (G)	+0.70 kg/m² for GG genotype^c	[84]
rs7566605	2	118,552,495	INSIG2	9,881	37% (C)	+1.00 kg/m² for CC genotype	[121]
rs7647305	3	187,316,984	SFRS10, ETV5, DGKG	25,344	77% (C)	+0.54 kg/m² for CC genotype^c	[84]
rs10938397	4	45,023,455	GNPDA2	32,387	48% (G)	+0.19 kg/m² per G allele^b	[92]
rs4712652	6	22,186,593	PRL	2,796	41% (A)	+0.031 kg/m² per A allele in children^d	[126]
rs10508503	10	16,339,956	PTER	2,796	8.5% (C)	+0.144 kg/m² per C allele in children^d	[126]
rs6265 (V66M)	11	27,636,492	BDNF	25,344	85% (G)	+0.67 kg/m² for GG genotype^c	[84]
rs10838738	11	47,619,625	MTCH2	32,387	34% (G)	+0.07 kg/m² per G allele^b	[92]
rs7138803	12	48,533,735	BCDIN3D, FAIM2	25,344	37% (A)	+0.54 kg/m² for AA genotype^c	[84]
rs7498665	16	28,790,742	SH2B1	32,387	41% (G)	+0.15 kg/m² per G allele^b	[92]
rs7498665	16	28,790,742	SH2B1, ATP2A1	25,344	44% (G)	+0.45 kg/m² for GG genotype^c	[84]
rs8050136	16	52,373,776	FTO	25,344	41% (A)	+1.07 kg/m² for AA genotype^c	[84]
rs9939609	16	52,378,028	FTO	38,759	40% (A)	+0.40 kg/m² per A allele	[95]
rs9939609	16	52,378,028	FTO	32,387	41% (A)	+0.33 kg/m² per A allele^b	[92]
rs1421085	16	52,358,455	FTO	2,796	40% (C)	+0.112 kg/m² per C allele^d	[126]
rs1424233	16	78,240,251	MAF	2,796	43% (A)	+0.091 kg/m² per A allele in children^d	[126]
rs1805081	18	19,394,429	NPC1	2,796	44% (A)	−0.087 kg/m² per A allele in children^d	[126]
rs17782313	18	56,002,077	MC4R	16,876	24% (C)	+0.22 kg/m² per C allele	[85]
rs17782313	18	56,002,077	MC4R	32,387	22% (C)	+0.22 kg/m² per C allele^b	[92]
rs17782313	18	56,002,077	MC4R	2,796	17,5% (C)	+0.097 kg/m² per C allele^d	[126]
rs12970134	18	56,035,730	MC4R	25,344	30% (A)	+0.36 kg/m² for AA genotype^c	[82]
rs52820871 (I251L)	18	56,189,806	MC4R	16,797	0.75% (251L)	−0.35 SD of their BMI Z-score per 251L allele	[71]
rs2229616 (V103I)	18	56,190,256	MC4R	7,713	2% (103I)	−0.48 kg/m² per 103I allele	[70]
rs29941	19	39,001,372	CHST8, KCTD15	25,344	70% (C)	+0.46 kg/m² for CC genotype^c	[84]
rs11084753	19	39,013,977	KCTD15	32,387	67% (G)	+0.06 kg/m² per G allele^b	[92]

^aEither in the GWAS or the initial sample

^bReported in the population-based cohorts EPIC, FINRISK97, BPPP and METSIM (N = 18,812; [92])

^cReported for the Islandic sample (N = 25,344; [84])

^dreported for children from the Northern Finland Birth Cohort (N = 5,291; [126]), adapted from [86]

NEGR1: neuronal growth factor regulator 1; SEC16B; cerevisiae, homolog of, B; RASAL2: RAS protein activator like 2; TMEM18: transmembrane protein 18, INSIG2: insulin induced gene 2, SFRS10: splicing factor, arginine/serine-rich, 10; ETV5: ets variant 5; DGKG diacylglycerol kinase, gamma, 90kD, GNPDA2: glucosamine-6-phosphate deaminase 2; PRL: prolactin; PTER: phosphotriesterase related; BDNF: brain derived neurotrophic factor; MTCH2: mitochondrial carrier homolog 2 (C. elegans); BCDIN3D: BCDIN3 domain containing; FAIM2: Fas apoptotic inhibitory molecule 2; SH2B1: SH2B adaptor protein 1; ATP2A1: ATPase, Ca++ transporting, cardiac muscle, fast twitch 1; FTO: fat mass and obesity associated; MAF: v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian); NPC1: Niemann-Pick disease, type C1; MC4R: melanocortin 4 receptor; CHST8: carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8; KCTD15: potassium channel tetramerisation domain containing 15