Figure 2. Human APOBEC3G Cosediments with Ty1 VLPs.
(A) Western blot analysis of sucrose gradient fractions of cell lysates from strain JC3212 expressing APOBEC3G or no APOBEC with rabbit antiserum specific for Ty1 Gag (top) or anti-HA antibodies (bottom). For each strain, 10 ug of whole cell lysate (IN), 7 μl (1×) and 0.7 μl (0.1×) of the 45% fraction of the first sucrose gradient and 11.5 μl of the first and then every third fraction of the second 20% to 60% gradient (20%–60%) were analyzed.
(B) Similar to (A) except an spt3 strain expressing APOBEC3G was analyzed with anti-HA antibodies.