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The diagram depicts the minimal protein activity required at a DNA replication fork, including the DNA-unwinding helicase, single-stranded DNA-binding protein (RPA), primase (Pol α), leading strand polymerase (Pol δ), lagging strand polymerase (Pol δ and/or Pol ε), circular sliding clamp (PCNA), and the clamp loader (RFC), which must catalyze PCNA assembly at multiple primed sites during lagging DNA strand synthesis.
