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. Author manuscript; available in PMC: 2010 Mar 16.
Published in final edited form as: J Biol Chem. 2002 Oct 4;277(49):47213–47224. doi: 10.1074/jbc.M206764200

Fig. 9. A model for rapid recognition of primed DNA sites by RFC at the DNA replication fork.

Fig. 9

During DNA replication, the RFC clamp loader can transiently interact with single- and double-stranded DNA at the replication fork until it recognizes a primed DNA site, where it pauses to assemble a clamp. The ability to scan DNA rapidly as well as bind a primer-template structure with high specificity and stability among excess single- and double-stranded DNA may improve the efficiency with which RFC catalyzes clamp assembly at primed DNA sites.