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. Author manuscript; available in PMC: 2010 Mar 16.
Published in final edited form as: Annu Rev Biochem. 2009;78:119–146. doi: 10.1146/annurev.biochem.78.082907.145923

Figure 1.

Figure 1

Map of an early R plasmid R100. Tetracycline resistance gene tetA is in the transposon Tn10, chloramphenicol acetyltransferase (cat) as a part of Tn9, and sulfonamide resistance gene sul1 and an aminoglycoside adenyltransferase gene aadA1 as a part of the large transposon Tn21. The resistance genes are color coded, and the direction of transcription is shown by the arrows. Much of the blank areas outside the transposons are occupied by the transfer genes, needed for the formation of relaxosomes, the coupling factor, and the mating-pair formation. This figure is based on the nucleotide sequence deposited by (30) and GenBank sequence NC 002134, submitted by G. Sempei and K. Mizobuchi. ΔqacE is a defective version of a gene coding for a multidrug efflux pump of Smr family (see text).