Figure 2.

(Left) Schematic representation of Tpr-Met and Tpr-Sea proteins. White boxes represent the Tpr moiety; gray boxes represent the Met tyrosine kinase domain; the black box represents the Sea tyrosine kinase domain. YVHV-YVNV indicates the sequence of the Met multifunctional docking site; YVNL-YVNL indicates the sequence of the Sea multifunctional docking site. The N, critical for Grb2 binding, is underlined. (Right) Transformation refers to ability to induce foci of transformation, expressed as relative transforming activity (percent of Tpr-Met wild type). Metastasis indicates percentage of mice dead because of lung metastases, 3 weeks after injection of 10⁶ cells into the tail vein.