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. Author manuscript; available in PMC: 2010 Mar 16.
Published in final edited form as: FASEB J. 2003 Oct 16;17(15):2296–2298. doi: 10.1096/fj.03-0166fje

Figure 2. Inhibition of P-selectin-mediated, but not E-selectin-mediated, leukocyte cell tethering/rolling by PLNP under shear in vitro.

Figure 2

A) Selectin-blocking PLNP (1% PEG) or negative control PLNP (15% PEG) were administered after U-937 cell rolling was established on P-selectin-coated capillary tubes, and the number of cells interacting with the wall of the capillary tube was determined. B) Rolling of U937 cells was established on P-selectin chimera-coated capillary tubes, and the dose-dependent effect of P-selectin blocking PLNP was determined. C) Comparison of the inhibitory effect of selectin-blocking PLNP on U-937 interactions with P- or E-selectin chimera-coated capillary tubes. All data are representative of three to four independent experiments showing similar results.