Figure 2.
Effects on network activity due to a TNF-α increase. (a) Changes in average neuronal activity after chronic inflammation (external TNF-α values displayed in different colours; blue, 10−3; yellow, 10−5; red, 10−7). The severity of immune response (b) affects burst frequency and (c) induces an increase in the average firing rate. (d) Changes in average neuronal activity in the case of TNF-α overexpression by glia (for different c 0 values; blue, 2.0; yellow, 1.0; red, 0.5). The degree of overexpression affects (e) burst frequency and (f) the average firing rate. Results are averaged over 10 trials, with error bars indicating standard error.