Table 3.

Frequency of missense changes identified and their association with one another in the APC gene

	Number of times identified
Codon/Codon	545	1493	1499	1678	1756	1822	1960
545	13*	3	1	12	11	3	12
1493		9	0	5	5	4	7
1499			2	2	1	1	2
1678				40	17	18	35
1756					21	6	17
1822						23	20
1960							48

*number of times observed in the study population