Table 6.
Missense changes identified in exon 15 of the APC gene
| Exon | Nucleotide | Codon | Reported in Human Genome Database | Number of observations | New |
|---|---|---|---|---|---|
| 15.5 | 3386 T>C | L1129S | No | 2 | Yes |
| 15.7 | 3949 G>C | E1317Q | Yes | 2 | No |
| 15.8 | 4237 A>G* | M1413V | No | 1 | Yes |
| 15.10 | 4918 C>T | R1640W | Yes | 1 | No |
| 15.12 | 5465 A>T* | D1822V | Yes | 23 | No |
| 15.19 | 7406 C>T* | S2469F | No | 2 | Yes |
| 15.19 | 7504 G>A* | G2502S | No | 3 | Yes |
| 15.20 | 7862 C>G | S2621C | Yes | 2 | No |
| 15.21 | 8068 G>A | A2696T | No | 1 | Yes |
*Causative mutation identified in patients harbouring these missense changes