Table 3. Effect of concomitant treatment with BENSpm and chemotherapeutic drugs on Hs578t, T47D, and MCF-10A cells.

Combination index (CI) values for fractional growth inhibitions of 0.50, 0.75, and 0.90 are shown for combination studies using BENSpm with chemotherapeutic drugs for a 120 hour concomitant treatment. CI values were determined as described in Materials and Methods. Values are the means ± SD of three experiments. Synergy CI < 1.00; additivity CI = 1.00; antagonism CI > 1.00.

Hs578t cells
	Fractional Growth Inhibition
	0.5	0.75	0.9
FdUrd	0.908 ± 0.188	0.867 ± 0.103	0.852 ± 0.098
5-FU	0.875 ± 0.157	0.843 ± 0.147	0.678 ± 0.128
C-DDP	1.357 ± 0.216	1.906 ± 0.218	1.792 ± 0.145
Paclitaxel	0.306 ± 0.073	0.355 ± 0.069	0.453 ± 0.089
Docetaxel	1.009 ± 0.139	0.995 ± 0.184	0.984 ± 0.110
Vinorelbine	1.405 ± 0.156	1.579 ± 0.261	1.883 ± 0.117
T47D cells
	Fractional Growth Inhibition
	0.5	0.75	0.9
FdUrd	0.847 ± 0.142	0.871 ± 0.167	0.899 ± 0.127
5-FU	0.865 ± 0.132	0.951 ± 0.049	0.811 ± 0.065
C-DDP	0.825 ± 0.059	0.949 ± 0.148	0.903 ± 0.054
Paclitaxel	0.473 ± 0.137	0.411 ± 0.111	0.366 ± 0.119
Docetaxel	0.882 ± 0.211	0.807 ± 0.249	0.792 ± 0.129
Vinorelbine	0.665 ± 0.101	0.591 ± 0.284	0.679 ± 0.179
MCF-10A cells
	Fractional Growth Inhibition
	0.5	0.75	0.9
FdUrd	1.907 ± 0.137	1.711 ± 0.121	1.937 ± 0.138
5-FU	1.797 ± 0.219	1.526 ± 0.231	1.843 ± 0.122
C-DDP	1.606 ± 0.116	1.716 ± 0.165	1.835 ± 0.169
Paclitaxel	0.606 ± 0.117	0.635 ± 0.154	0.682 ± 0.216
Docetaxel	1.557 ± 0.125	1.712 ± 0.165	1.208 ± 0.237
Vinorelbine	1.221 ± 0.203	1.767 ± 0.165	1.527 ± 0.187