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. Author manuscript; available in PMC: 2011 Mar 1.

Published in final edited form as: Hepatology. 2010 Mar;51(3):796–805. doi: 10.1002/hep.23391

Expression of betaine-homocysteine methyltransferase (BHMT) and selective ER stress markers in the livers of mice versus rats fed alcohol intragastrically or fed a high methionine low folate diet (HMLF) orally. Panel A, Western blots of BHMT; Panel B, relative BHMT protein expression normalized to β-actin; Panel C, Western blots of ER markers; Panel D, relative levels of ER markers normalized to β-actin; CF, pair-fed control; E or EtOH, fed alcohol; H or HM, fed HMLF; GRP78, glucose regulated protein 78; SREBP1, sterol regulatory element binding protein 1; IRE1, the type I transmembrane protein kinase endoribonucleases. *, p<0.05; **, p<0.01 compared between CF and EtOH, or between CF and HM; ^α, p<0.05 compared between mice and rats; n = 3

Expression of betaine-homocysteine methyltransferase (BHMT) and selective ER stress markers in the livers of mice versus rats fed alcohol intragastrically or fed a high methionine low folate diet (HMLF) orally. Panel A, Western blots of BHMT; Panel B, relative BHMT protein expression normalized to β-actin; Panel C, Western blots of ER markers; Panel D, relative levels of ER markers normalized to β-actin; CF, pair-fed control; E or EtOH, fed alcohol; H or HM, fed HMLF; GRP78, glucose regulated protein 78; SREBP1, sterol regulatory element binding protein 1; IRE1, the type I transmembrane protein kinase endoribonucleases. *, p<0.05; **, p<0.01 compared between CF and EtOH, or between CF and HM; ^α, p<0.05 compared between mice and rats; n = 3