Table 2.

Features of the 11q-del and MNA phenotypes

MNA group	11q-del group
Amplification of MYCN	No amplification of MYCN*
No 11q deletion*	11q deletion
Few segmental aberrations (median, 4)	Many segmental aberrations (median, 12)
Chromosomal breaks on few other chromosomes in addition to chromosome 2 (location of MYCN)	Chromosomal breaks on several chromosomes in addition to chromosome 11
Break distribution ”more focused”	Break distribution ”more shotgun-like”
1p deletion region more proximal on 1p (consensus in 17–32 Mb)	1p deletion region more distal on 1p (consensus in 0–10.4 Mb)
Poor prognosis; 8-year survival ∼35%	Poor prognosis; 8-year survival ∼35%
Median age at diagnosis 21 months	Median age at diagnosis 42 months
Median survival from diagnosis 16 months	Median survival from diagnosis 40 months
Significantly higher H2AFX expression†	Significantly lower H2AFX expression†

^*Only rare cases of both MNA and 11q-deletion in the same tumor.

^†In NB primary tumors and cell lines.