Table 1.
Characteristics of PLG Nanoparticles Coated With Cationic and Anionic Materials
| PVAm | Chitosan | DC-Chol | Cetrimide | Protamine | DODAB | PVA | Pluronic F-127 | |
|---|---|---|---|---|---|---|---|---|
| % (w/v)a | 0.03 | 0.03 | 0.02 | 0.1 | 0.02 | 0.02 | 2.0 | 0.1 |
| Size ± SD (nm) | 196 ± 4 | 201 ± 1 | 167 ± 1 | 197 ± 2 | 204 ± 3 | 163 ± 4 | 137 ± 2 | 169 ± 2 |
| Polydispersity | 0.145 | 0.168 | 0.068 | 0.145 | 0.022 | 0.074 | 0.099 | 0.122 |
| Zeta potential ± SD (mV) | +37.5 ± 0.8 | +36.8 ± 0.4 | +33.2 ± 0.7 | +35.4 ± 1.6 | +17.7 ± 1.4 | +40.9 ± 0.9 | −11.0 ± 2.0 | −23.2 ± 1.1 |
| pDNA loading (%) | 1.08 | 1.06 | 1.10 | 1.14 | 1.09 | 1.12 | 1.00 | 1.03 |
| Encapsulation efficiency (%) | 83.1 ± 1.2 | 81.5 ± 2.3 | 84.6 ± 0.7 | 87.7 ± 0.5 | 83.8 ± 1.2 | 86.2 ± 0.2 | 77.0 ± 1.1 | 79.2 ± 0.5 |
a
Weight/volume percent (the concentration of the coating materials). Values are representative of three experiments (mean ± SD).