Table 1. Neuroticism and Extraversion Scores by BDNF Val66Met Genotypes.
|
BDNF genotype |
P-value | |||
|---|---|---|---|---|
| GG Val/Val | AG Val/Met | AA Met/Met | ||
| SardiNIA (N) | 707 | 694 | 159 | |
| Neuroticism | 55.0 (9.5) | 55.7 (9.2) | 55.5 (8.7) | 0.19 |
| Extraversion | 49.6 (8.9) | 47.5 (9.4) | 48.9 (8.8) | 0.005 |
| BLSA (N) | 770 | 324 | 37 | |
| Neuroticism | 46.8 (8.3) | 48.3 (8.6) | 44.2 (10.2) | 0.94 |
| Extraversion | 51.5 (9.9) | 49.1 (9.6) | 50.0 (10.2) | 0.02 |
| BLSA-Europeans (N) | 515 | 290 | 34 | |
| Neuroticism | 47.4 (8.4) | 48.4 (8.6) | 44.8 (9.9) | 0.74 |
| Extraversion | 50.8 (10.2) | 48.8 (9.9) | 49.7 (10.3) | 0.008 |
Abbreviations: BDNF, brain-derived neurotrophic factor; BLSA, Baltimore Longitudinal Study of Aging.
Raw personality domain scores (SD). P-values derived from association analyses carried out using MERLIN controlling for sex, age, and age2. In the full BLSA sample, eigenvalues were used as additional covariates to control for population stratification.