Table 1.
Cre driver lines that have been characterized
| Cre line* | Reporter | CISH data | DFISH data | XFP data | Expression highlight# | JAX or MMRRC # |
|---|---|---|---|---|---|---|
| 8030451F13Rik-Tg2-Cre | Ai9 | tdTomato, Cre | tdTomato/Gad1 | tdTomato | Scattered populations in the cortex and hippocampus | JAX #008848 |
| Ai2 | EYFP | |||||
| A930038C07Rik-Tg4-Cre | Ai9 | tdTomato, Cre | tdTomato/Gad1 | tdTomato | Scattered populations enriched in layers 3/4/5 | JAX #009616 |
| Camk2a-Cre38 | Ai2 | EYFP, Cre | EYFP/Gad1 | EYFP | Widespread in forebrain areas, e.g. cortex, hippocampus, striatum | JAX #005359 |
| Ai9 | tdTomato | tdTomato/Gad1 | tdTomato | |||
| Camk2a-CreERT2 (uninduced) $ | Ai14 | tdTomato | tdTomato/Gad1 | tdTomato | Scattered populations in cortex | |
| Ai6 | ZsGreen | |||||
| Camk2a-CreERT2 (induced) $ | Ai14 | tdTomato | tdTomato/Gad1 | tdTomato | Widespread in forebrain areas, e.g. cortex, hippocampus, striatum | |
| Ai6 | ZsGreen | |||||
| Chat-Cre | Ai9 | tdTomato, Cre | tdTomato/Chat, tdTomato/Gad1 | tdTomato | Cholinergic neurons | JAX #006410 |
| Ai6 | ZsGreen | |||||
| Drd1a-Cre39 | Ai3 | EYFP, Cre | EYFP/Gad1, EYFP/Drd1a | EYFP | Striatum and cortex | |
| Ai9 | tdTomato | tdTomato | ||||
| Emx1-ires-Cre40 | Ai9 | tdTomato, Cre | tdTomato/Gad1, Emx1/tdTomato | tdTomato | Widespread in cortex | JAX #005628 |
| Erbb4-2A-CreERT2 (induced) $ | Ai14 | tdTomato, Cre | tdTomato/Gad1, Pvalb/tdTomato, Erbb4/tdTomato | tdTomato | Scattered interneuron populations in cortex, hippocampus | |
| Gfap-Cre41 | Ai3 | EYFP | Gfap/EYFP | Both astrocytes and widespread neuronal expression | JAX #004600 | |
| Ai6 | ZsGreen, Cre | Gfap/ZsGreen | ZsGreen | |||
| Ntsr1-Cre27 | Ai3 | EYFP | EYFP/Gad1 | EYFP | Layer 6 specific | MMRRC #017266 |
| Ai14 | tdTomato | tdTomato/Gad1 | tdTomato | |||
| Pvalb-2A-Cre | Ai14 | tdTomato | tdTomato/Gad1, Pvalb/tdTomato | tdTomato | Pvalbumin-positive interneurons and excitatory neurons in layer 5 | |
| Ai9 | tdTomato, Cre | tdTomato/Gad1, Pvalb/tdTomato | tdTomato | |||
| Pvalb-ires-Cre34 | Ai14 | tdTomato, Cre | tdTomato/Gad1, Pvalb/tdTomato | tdTomato | Pvalbumin-positive interneurons | JAX #008069 |
| Ai9 | tdTomato | tdTomato/Gad1, Pvalb/tdTomato | tdTomato | |||
| Pcp2-Cre26 | Ai2 | EYFP | Pcp2/EYFP | EYFP | Purkinje cells, scattered population of cells (glial) throughout the brain, also enriched neuronal expression in visual cortex | JAX #006207 |
| Ai9 | tdTomato | Pcp2/tdTomato | tdTomato | |||
| Ai6 | ZsGreen, Cre | ZsGreen | ||||
| Ai3 | EYFP | EYFP | ||||
| Pomc-Cre4 | Ai3 | EYFP, Cre | EYFP/Pomc1 | EYFP | POMC-positive neurons in hypothalamus, also in dentate gyrus | JAX #005965 |
| Ai9 | tdTomato | |||||
| Scnn1a-Tg1-Cre | Ai9 | tdTomato, Cre | tdTomato/Gad1 | tdTomato | Enriched in layer 4, plus scattered widespread expresssion | JAX #009111 |
| Scnn1a-Tg2-Cre | Ai9 | tdTomato, Cre | tdTomato/Gad1 | tdTomato | Very sparse cells in layer 4, mostly in somatosensory area | JAX #009112 |
| Scnn1a-Tg3-Cre | Ai9 | tdTomato, Cre | tdTomato/Gad1 | tdTomato | Layer 4 specific | JAX #009613 |
| Six3-Cre32 | Ai3 | EYFP | EYFP/Gad1 | EYFP | Enriched in layer 4, plus scattered populations in cortex, striatum | |
| Ai9 | tdTomato | tdTomato/Gad1 | tdTomato | |||
| Slc6a3-Cre25 | Ai3 | EYFP, Cre | EYFP/Slc6a3 | EYFP | Dopamine neurons, plus sparse populations elsewhere | |
| Ai9 | tdTomato | Slc6a3/tdTomato | tdTomato | |||
| Wfs1-Tg2-CreERT2 (induced) $ | Ai9 | tdTomato, Cre | tdTomato/Gad1 | tdTomato | Enriched in layers 2/3 | JAX #009614 |
| Wfs1-Tg3-CreERT2 (induced) $ | Ai9 | tdTomato, Cre | tdTomato/Gad1 | tdTomato | Enriched in layers 2/3 plus scattered populations in cortex | JAX #009103 |
*
Cre lines in bold are newly generated lines.
#
Expression highlights describe only the most relevant cell populations targeted by the Cre lines, not including all the cell populations where Cre-recombination occurs.
$
Induced or uninduced refers to with or without tamoxifen treatment for CreERT2-containing mice.