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Bystander effect in vivo. Different ratios of SSV9AFABTKneo virus transduced and untransduced PLC/PRF/5 cells were inoculated to the right flank of the mice. GCV treatment started when tumor size was ≤1 cm in diameter. The tumor growth was calculated as described in Fig. 2. Complete shrinkage of tumors were obtained when the ratios of TK+: TK− were 10:0, 9:1, and 1:1.
