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. 2010 Jan 26;107(7):3012–3017. doi: 10.1073/pnas.0914902107

Fig. 1.

Fig. 1.

Poly (I:C) induces severe proliferative glomerulonephritis with crescents. Untreated nonproteinuric, untreated spontaneously proteinuric, and poly (I:C)-treated proteinuric NZB/W mice, were analyzed after 14 days of proteinuria. (A) Paraffin-embedded kidney sections stained for basement membrane and matrix constituents with periodic acid shiff stain (PAS). (B) Glomerular and interstitial histological scores. Each symbol indicates an individual mouse (n = 4–11 mice per group). **, P < 0.01. (C) Mice were treated with poly (I:C) for the indicated duration of treatment and analyzed after the indicated duration of proteinuria; kidney cortex mRNA was analyzed by real-time RT-PCR for ISG15 and STAT1; values are relative to expression of the gene encoding GAPDH (n = 4–6 mice per group). *, P < 0.05.