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. 2010 Jan 28;107(7):3198–3203. doi: 10.1073/pnas.0915020107

Fig. 3.

Fig. 3.

Blockade of LTD by COX-2 inhibitor and rescue by PGD2/E2. (A) LTD blockade by 10-min perfusions of COX-2 inhibitor (NS-398) at various times relative to conjunction. (B) Profile of time window mapped with 5- or 10-min perfusions of NS-398, illustrated similarly to Fig. 2D. (C) Rescue by 5-min perfusions of PGE2 of the LTD that was blocked by infusion of NS-398. (D) Mapping the receptiveness of LTD induction mechanisms to 5-min perfusion of PGE2, similar to Fig. 2F. (E) LTD rescued by 5-min perfusion of PGE2 in cPLA2α KO PC. (F) Synergy between perfused TPA and PGE2 in inducing LTD.