Fig. 1.
Virus infection rapidly induces IL-10 production. (A) Virus titers in the serum at the indicated day following i.v. infection with 2 × 106 PFU LCMV-Arm (black circles) or Cl 13 (gray circles). Each circle represents the average virus titer (PFU) ± SD at the indicated day after infection. The dashed line indicates the level of detection of the assay (200 PFU/g spleen). (B) IL-10 protein concentration in the serum of LCMV-Arm or Cl 13 infected mice. (C) Virus titers in the spleen of WT C57BL/6 and IL-10 KO mice after infection with 2 × 106 PFU LCMV-Arm. Each circle represents an individual mouse. Data are representative of four to five mice per group and two independent experiments.