Table 1.
Nomenclature and properties of fatty acid transport proteins.
| Gene id | Nomenclature | Tissue | Regulation | Substrate, ligand, or binding protein | Subcellular location | Function |
|---|---|---|---|---|---|---|
| SLC27A1 | FATP1-ACSVL4 | Heart, adipose, muscle, brain | PPARγ | C16:0, C18:1, C24:0 | Mitochondria | β-oxidation |
| Plasma | TAG synthesis | |||||
| membrane | ||||||
| SLC27A2 | FATP2-ACSVL1 | Liver, kidney | PPARα, PPARγ | C16:0, C24:0 | Endoplasmic | TAG synthesis |
| Phytanic acid, | reticulum | β-oxidation | ||||
| pristanic acid, | Peroxisome | |||||
| SLC27A3 | FATP3-ACSVL3 | Kidney, ovary, lung, brain, adrenal, testis | C16 :0, C18:1, C24:0 | Cytosolic vesicles | unknown | |
| SLC27A4 | FATP4-ACSVL5 | Liver, kidney, heart, adipose, skin, muscle, small intestine | PPARγ, SREBP1c | C16:0, C24:0 | Endoplasmic | TAG synthesis |
| reticulum | β-oxidation | |||||
| Peroxisome | ||||||
| SLC27A5 | FATP5-ACSVL6 | Liver | Cholate, THCA | Endoplasmic | Bile acid conjugation | |
| Chenodeoxycholate | reticulum | Bile acid synthesis | ||||
| Lithocholate, C24:0 | Peroxisome | |||||
| Deoxycholate | ||||||
| SLC27A6 | FATP6-ACSVL2 | Heart, placenta | C18:1, C20:4, C24:0 | Plasma membrane | unknown | |
| FABP1 | L-FABP | Liver, Intestine | PPARα, HNF4α | Acyl-CoA, PPARα, γ | Cytosol, nucleus | |
| FABP2 | I-FABP | Intestine | Acyl-CoA | Cytosol | TAG synthesis | |
| FABP3 | H-FABP | Heart, kidney | c/EBPα, SREBP1 | Acyl-CoA, PPARα | Cytosol | β-oxidation |
| muscle, thymus | AP-1 | |||||
| FABP4 | A-FABP | Heart, adipose, | cJun, PPARγ | Acyl-CoA, PPARγ | Cytosol | Chylomicron |
| Epidermis, nerve | assembly | |||||
| FABP5 | E-FABP | Eye, adipose, testis | PPARδ | Acyl-CoA, PPARδ | Cytosol | lipogenesis |
| FABP6 | Il-FABP | Ileum | Acyl-CoA, FXRα | Cytosol | ||
| FABP7 | B-FABP | Liver, brain | POU | Acyl-CoA | ||
| FABP8 | N-FABP | Myelin | Acyl-CoA | Cytosol | Vesicle assembly | |
| FABP9 | T-FABP | Testis | Acyl-CoA | Cytosol | ||
| FABP12 | R-FABP | Retina,testis | Acyl-CoA | Cytosol | ||
| ACBP | L-ACBP | Liver, multiple tissues | PPARα, c/EBPα | C14:0–C22:0 acyl-CoA esters, HNF4α | Cytosol | Glycerolipid, cholesterol synthesis |
| SREBP1c, Sp1 | ||||||
| PPARγ | ||||||
| ACBP | T-ACBP | Testis, adrenal | C14:0–C22:0 acyl-CoA esters | Cytosol, endoplasmic reticulum | ||
| ACBP | B-ACBP | Brain | C14:0–C22:0 acyl-CoA esters | Cytosol |
Characteristics of fatty acid transport protein (FATP-ACSVL), fatty acid binding protein (FABP), and acyl-CoA binding protein (ACBP). This table summarizes tissue specific expression, regulation by transcription factors, substrate, ligand binding, and interaction with nuclear receptors and putative function in the metabolism of fatty binding proteins.