TABLE 2.
Sociodemographic, Clinical, and Treatment Characteristics of the Treatment Group
| Study of Origin |
||||||||
|---|---|---|---|---|---|---|---|---|
| Variable | Total Group (N=461) | Maintenance Therapies in Late-Life Depression 1 (N=168) | Maintenance Therapies in Late-Life Depression 2 (N=183) | Double-Blind Randomized Comparison of Nortriptyline and Paroxetine in Late-Life Depression (N=110) | ||||
| N | % | N | % | N | % | N | % | |
| Inpatient statusa | 105 | 23 | 31 | 18 | 18 | 10 | 56 | 51 |
| Female | 322 | 70 | 126 | 75 | 117 | 64 | 79 | 72 |
| Caucasian | 415 | 90 | 156 | 93 | 166 | 91 | 93 | 85 |
| Recurrent episode | 291 | 63 | 168 | 100 | 73 | 40 | 50 | 46 |
| Pharmacotherapy | ||||||||
| Nortriptyline | 217 | 47 | 168 | 100 | — | 49 | 45 | |
| Paroxetine | 244 | 53 | — | 183 | 100 | 61 | 55 | |
| Median | Median | Median | Median | |||||
| Duration of current episode (weeks) | 26.0 | 17.8 | 40.0 | 26.0 | ||||
| Mean | SD | Mean | SD | Mean | SD | Mean | SD | |
| Age (years) | 72.5 | 7.4 | 67.8 | 5.8 | 77.1 | 5.6 | 71.8 | 7.6 |
| Education (years) | 12.5 | 2.7 | 12.5 | 2.5 | 12.9 | 2.9 | 11.9 | 2.7 |
| Age of illness onset | 57.5 | 18.5 | 48.6 | 16.2 | 63.9 | 18.3 | 60.3 | 16.9 |
| Cumulative Illness Rating Scale for Geriatrics total score | 8.9 | 4.0 | 7.4 | 3.3 | 10.0 | 4.1 | 9.3 | 4.0 |
| Mini-Mental State Examination score | 28.0 | 2.6 | 29.2 | 1.0 | 27.7 | 2.5 | 26.5 | 3.3 |
| Baseline 17-item Hamilton | 21.6 | 4.0 | 22.3 | 4.2 | 20.6 | 3.6 | 22.2 | 4.0 |
| Depression Rating Scale (HAM-D-17) score | ||||||||
| Baseline HAM-D-17 anxiety subscale score | 5.2 | 1.9 | 4.4 | 1.9 | 5.5 | 1.6 | 5.9 | 1.9 |
| Baseline HAM-D-17 sleep subscale score | 3.5 | 1.7 | 3.6 | 1.7 | 3.7 | 1.7 | 3.2 | 1.6 |
| Antidepressant treatment history form score | 1.5 | 1.4 | — | 1.6 | 1.5 | 1.3 | 1.4 | |
| Nortriptyline dose (mg/day) | — | 75 | 33 | — | 48 | 22 | ||
| Paroxetine dose (mg/day) | — | — | 26 | 11 | 23 | 7 | ||
a
Number of patients being treated as inpatients at the beginning of each study.