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. 2010 Feb 4;107(8):3418–3423. doi: 10.1073/pnas.0907774107

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Fig. 1. — Chondrogenic differentiation of isolated periosteal cells over 3 d. (A) Compared to normoxic conditions (21% O₂), after 3 d of differentiation under hypoxic conditions (0.2% O₂), mRNA expression levels of collagen Type II (COL 2) show an average 7-fold increase (range 3–18) whereas ACG mRNA expression is increased by an average of 2.8-fold (range 1.5–4.7), and Sox9 mRNA levels showed a 3.5-fold increase (range 1.5–6.2). The results of five independent periosteal isolates are shown. All mRNA levels were normalized to 28S rRNA. Standard deviation (SD) is indicated by error bars. (B) Western analysis confirms an increased level of COL2 protein under hypoxic conditions compared to normoxic conditions.