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Full thickness articular cartilage defect microfracture rabbit model. Surgical procedure creating (A) full thickness articular cartilage defects in rabbit trochlea using a microcurette and (B) microfracture holes through the subchondral bone using a microawl to induce bleeding into the defect. (C) PA gel in defect after injection (Arrow). (D) Pyrene-labeled PA gel illustrating containment of the gel within articular cartilage defects after injection.
