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Nerve blockade with 25mM QX-314 and Tween 20. (A) Effect of increasing concentrations of Tween 20 on the duration of nerve blockade. n = 8 for all except for 0 mM (i.e., 25 mM QX-314 alone), where n = 20. (B) Percent suppression of thermal nociception and motor function over time from 25 mM QX-314 + 4 mM Tween 20; n = 4. Data are medians with 25th and 75th percentiles. *P < 0.05; **P < 0.01, comparison of sensory and motor blocks. †See Fig. 1.
