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Leading six HCV entry inhibitors from small-molecule library screen. (A) Chemical structures. (B) Dose-dependent effects on entry of H77 HCVpp (shaded bars) and VSV-Gpp (open bars) into Huh-7.5 cells. The anti-CD81 antibody JS-81 (1 μg/mL) was included as a positive control for each dose–response. Drug cytotoxicity in the absence of pseudoparticle transduction (solid circles) was determined by CellTiter-Glo assay. Values are expressed as a percentage of 0.1% DMSO-treated cells.
